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Available tools:

HCAM - Hidropathy Clustering Assisted Method: a new method for protein secondary structure prediction by Kyte-Dolittle hydrophobic clustering and physicochemical profiles analysis. read more...

BBSP - Building Blocks Structure Predictor: a new method for both protein fold prediction and structural homologues search via fragment assembly and profile-profile comparison. Structural models validation is assisted by secondary structure and physicochemical patterns previously generated by HCAM method. You are encouraged to download BBSP for individual purposes, but at the same time we’ll be glade to receive the output results of your computation, mailing to biores@acbrc.org. This way you will save us a lot of computational time and will contribute to create a virtual worldwide infrastructure for distributed calculation. read more...

Available ongoing projects:

PBBD - Protein Building Blocks Database: a collection of basic PDB stand alone units (closed loops, αβ-barrels, helix-loop-helix, greek keys, coiled coils, βαβ-motifs, β-strands, EF hands, Zinc fingers, intrinsecally disordered regions, etc.) taken from several domain superfolds (Rossman folds, TIM barrels, αβ-sandwiches, αβ open sheets, etc.). At present the PBBD includes up to 7960 structures, ranging from 3 to 145 mers. Every effort to increase database size is welcomed: please, send a mail to biores@acbrc.org indicating the structures you found. read more...

IHN - Indiscernible Homology Network (coming soon): We have been using PBBD to construct a network of subdomain-size structural analogs sharing less than 20% aminoacidic identity for remote homology detection. A provisional set of BBSP results and remote homology structures is available in Tools section.